For hundreds of years, wine drinkers have been enjoying wine with cheese. The process of pairing the perfect wine with the perfect cheese has become an art that continues to evolve as wine and cheese experts continue to create new combinations.  The Early Pairings The earliest pairings involve wine and cheese choices from similar regions. The grapes and cows that produce the wine and cheese were often grown and raised on the same farms, so they offer some flavor similarities. For example, French Beaujolais is often paired with Brie, while Italian Chiantis is often paired with asiago cheeses.  The Science Behind Wine and Cheese Scientifically, there are several reasons why wine and cheese taste so good together. Wine offers an astringent flavoring in the mouth and the fat from cheese cleans the palate for the next flavor or another sip of wine. Wine and cheese have opposite flavor profiles, making them a pleasant combination – almost like opposite colors on a color wheel